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Gratifyingly, this frustrated state in these warheads allowed the development of cysteine targeting drugs with (a) higher selectivity compared to open-chain (acyclic) covalent inhibitors with an acrylamide warhead and (b) prominent GSH tolerance

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Vitamin C is a potent antioxidant both in plasma and within cells due to its ability to scavenge a wide range of reactive oxygen species, thereby protecting important biomolecules from oxidative damage (Hunnisett et al., 1995

Proposed dosing in the literature of ketone esters is 395573 mg/kg body weight to achieve blood BOHB of 3.3 mmol/L